Sepsis-Induced Myocardial Injury (SIMI) is a severe form of cardiac dysfunction that involves multiple mechanisms, including inflammatory damage and mitochondrial injury . Our research has demonstrated that MacroD1 plays a significant role in SIMI. By employing liquid chromatography-mass spectrometry (LC-MS) analysis to investigate the interactome of MacroD1, we have explored the mechanisms by which MacroD1 is involved in the pathogenesis of SIMI