In our study, we demonstrated that downregulation of arachidonate 15-lipoxygenase (ALOX15B) promotes KRASmut-PDAC tumour growth. In order to elucidate the mechanisms underlying downregulation of ALOX15B promoting KRASmut-PDAC progression, quantitative proteomics mass-spectrometry(MS) analysis of differential proteins in KRAS-mutant tissues was performed