PXD057643

PXD057643 is an original dataset announced via ProteomeXchange.

Title	Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival
Description	In this study, we identified the protein disulfide isomerase (PDI) enzymes PDIA1 and PDIA5 as critical mediators of prostate cancer cell growth and survival. Our research demonstrated that these enzymes have a multifaceted role in prostate cancer: they protect cells from oxidative stress, maintain mitochondrial function, and have important functions as regulators of androgen receptor (AR), a critical oncogenic driver. Indeed, targeting PDIA1/PDIA5 causes destabilization of AR protein, and combining PDI inhibitors with AR-targeting drugs boosted antitumor responses. This work positions PDIA1/PDIA5 as viable therapeutic targets.
HostingRepository	PRIDE
AnnounceDate	2025-10-15
AnnouncementXML	Submission_2025-10-14_23:54:40.646.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Sushma Ramesh Rao
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro; timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2024-11-07 18:58:06	ID requested
⏵ 1	2025-10-14 23:54:41	announced

10.1073/PNAS.2509222122;

submitter keyword: protein disulfide isomerase, prostate cancer, protein disulfide bond, androgen receptor

Luke A.
contact affiliation	Flinders Centre for Innovation in Cancer, Flinders University, Level 3, Flinders Centre for Innovation in Cancer Building, Flinders Drive, Bedford Park 5042, Australia.
contact email	luke.selth@flinders.edu.au
lab head
Sushma Ramesh Rao
contact affiliation	Fiona Elsey Cancer Research Institute
contact email	sushma@fecri.org.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD057643

PRIDE project URI

• PRIDE
  1. PXD057643
     1. Label: PRIDE project
     2. Name: Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival