To explore host factors and pathways modulated by coronavirus infections, we performed global quantitative proteomics profiling. Huh7 cells were infected with SARS-CoV-2 (MOI=1.0), HCoV-229E (MOI=0.1), or HCoV-OC43 (MOI=1.0) for 24 hours, compared with MOCK infection. Protein samples were digested and analyzed using mass spectrometry with a data-independent acquisition (DIA) approach to measure changes in global protein abundance. This study complements the phosphoproteomics dataset (PXD057224) from the same study