This study aims to investigate the neuroprotective effects of semaglutide in Diabetes-associated cognitive decline (DACD), while also exploring the underlying mechanisms targeting anti-oxidative effects.Methods: This study evaluated the antioxidant properties of semaglutide in a DACD model. To investigate the underlying mechanisms, we employed omics technologies. Proteomic analyses of the cells were conducted to identify the pathways responsible for the observed antioxidant effects.