PXD056694

PXD056694 is an original dataset announced via ProteomeXchange.

Title	Calorie Restriction Modulates Four Hallmarks of Aging in Prediabetic Adults: A Proteomics PREVIEW Sub-Study
Description	Prediabetes, a metabolic condition marked by impaired fasting glucose and/or glucose tolerance, is associated with multi-organ damage, heightened mortality risk, and accelerated aging, even prior to the onset of diabetes. Calorie restriction (CR) without depriving essential nutrients is one of the most effective dietary interventions for improving metabolic health and halting the progression to type 2 diabetes. However, how CR modulates aging-related processes, particularly at the systemic proteome level, remains incompletely understood in individuals at risk of diabetes. In this study, we employed targeted and untargeted proteomic approaches to evaluate the impact of an 8-week, 40-50% energy-restricted diet in 44 prediabetic adults from Sydney, Australia, enrolled in the PREVIEW study. Informed consent was obtained from all participants, who achieved ≥12% body weight loss during the intervention. Longitudinal changes in 2,059 circulating proteins were analyzed to investigate the systemic effects of CR on aging-related pathways.
HostingRepository	PRIDE
AnnounceDate	2025-07-11
AnnouncementXML	Submission_2025-07-11_09:21:55.880.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Laura Dagley
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2024-10-10 07:35:03	ID requested
⏵ 1	2025-07-11 09:21:56	announced

10.1111/ACEL.70123;

submitter keyword: LC-MS, extracellular vesicles,Calorie restriction, plasma

Prof. Luigi Fontana
contact affiliation	Professor of Medicine and Nutrition Leonard P. Ullman Chair in Translational Metabolic Health Scientific Director, Charles Perkins Centre Royal Prince Alfred Clinic Director of the 'Health for Life' Research, Educational and Clinical Program
contact email	luigi.fontana@sydney.edu.au
lab head
Laura Dagley
contact affiliation	WEHI
contact email	dagley.l@wehi.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD056694

PRIDE project URI

• PRIDE
  1. PXD056694
     1. Label: PRIDE project
     2. Name: Calorie Restriction Modulates Four Hallmarks of Aging in Prediabetic Adults: A Proteomics PREVIEW Sub-Study