The present studies consist of five proteomic experiments: proteomic profiling treated by apigenin; DARTS coupled MS analysis to identify the potential directed proteins targets of apigenin; Identification of the potential directed protein targets of biotin-apigenin by pull-down coupled MS analysis; proteomic profiling of senescent cells upon treatment with MJ33; Identification of the proteins interacting with PRDX6 by Co-IP coupled MS analysis.