Here, we analysed the global proteome of visceral, subcutaneous and brown adipose as well as liver tissues in a C57BL/6J mouse model of diet-induced obesity, following dietary exposure to 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH). This study includes data on male and female mice, as well as on immediate DINCH exposure and retained effects after a recovery phase.