PXD054628

PXD054628 is an original dataset announced via ProteomeXchange.

Title	Exosomes of Human blood plasma Lc-MS/MS
Description	Immunoglobulin diversity includes B-cell receptor, T-cell receptor, and antibody diversity. Existing studies focus more on the role of B-cell and T-cell receptor diversity in tumor immunity, while little is known about antibody diversity. This study examined and compared the blood exosomes of lung cancer patients and healthy individuals via proteomics and bioinformatics analyses. The results showed that of the 270 identified proteins, those enriched in the defense mechanism items were the most abundant. Most were antibody subtype molecules, accounting for 50.00%. Similarly, of the 40 identified exosomal DEPs, 29 were enriched in the defense mechanism items (72.50%), with a higher proportion of antibody subtypes (82.76%). Furthermore, 24 DEP antibody molecules were involved in 18 immune reaction-related signaling pathways. These results indicated that human serum exosomes contained a large number of antibody molecules, while the antibody subtypes from the lung cancer serum exosomes differed from those of the healthy controls. The variation in antibody diversity may be closely related to LA tumor immunity.
HostingRepository	PRIDE
AnnounceDate	2025-05-07
AnnouncementXML	Submission_2025-05-06_23:32:53.051.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	bhpsky 巴红平
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-08-06 01:42:14	ID requested
⏵ 1	2025-05-06 23:32:54	announced

Huang X, Xiong L, Zhang Y, Peng X, Ba H, Yang P, Proteomic profile of the antibody diversity in circulating extracellular vesicles of lung adenocarcinoma. Sci Rep, 14(1):27953(2024) [pubmed]

10.1038/s41598-024-78955-6;

submitter keyword: Human, blood, Plasma, Lc-MS/MS, Exosomes

Yang peng
contact affiliation	Department of Clinical Laboratory The Second Affiliated Hospital Guizhou University of Traditional Chinese Medicine
contact email	1874660968@qq.com
lab head
bhpsky 巴红平
contact affiliation	Department of Quality Evaluation Wuhan Center for Clinical Laboratory No. 24, Jianghan North Road, Jiang'an District, Wuhan 430400, China
contact email	bhpsky@163.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD054628

PRIDE project URI

• PRIDE
  1. PXD054628
     1. Label: PRIDE project
     2. Name: Exosomes of Human blood plasma Lc-MS/MS