Chronic kidney disease remains an unmet clinical challenge. It is only detected at advanced stages by current markers. Therefore, early detection of chronic kidney disease is vital. In this study, we profiled the urinary proteome in patients with albuminuria with well-preserved eGFR. We identi-fied 80 proteins that were differentially abundant between cases (albuminuria) and controls (normoalbuminuria). Among these, 12 proteins (SERPINA1, ALB, SERPINC1, AFM, PIGR, A1BG, COL6A1, MYG, LV39, MUC1, ICOSLG, and UMOD) had the highest discriminating abilities (area under curve > 0.8) between cases and controls. When differentially abundant proteins were com-bined into an 80-protein model, the model was able to predict cases from controls with predictive accuracy of 91.3%. The top five enriched biological pathways associated with differentially abundant proteins included insulin growth factor functions, innate immunity, platelet degranula-tion, and extracellular matrix organization.