PXD054039

PXD054039 is an original dataset announced via ProteomeXchange.

Title	Serum Alpha-2-Macroglobulin Links Type 1 Diabetes Status and Incident Cardiovascular Disease
Description	Background: Cardiovascular disease (CVD) is a leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM), with conventional risk factors not fully explaining the heightened risk. Study Design: We conducted a cross-sectional study comparing serum protein levels in 134 participants with T1DM from the Coronary Artery Calcification in Type 1 Diabetes study to 47 healthy controls, followed by a case-cohort study among 181 T1DM participants, including 47 with CVD events. Linear regression analyzed serum protein levels by diabetes status, while Cox proportional hazards regression assessed associations with incident CVD. Findings: Among 28 serum proteins tested, five showed significant differences between T1DM patients and controls, with alpha-2-macroglobulin (A2M) being notably 1.6-fold higher in T1DM. Adjusted models revealed that A2M (mean hazard ratio [HR] 2.5, 95% confidence interval [CI] 1.5-4.1) and apolipoprotein C3 (APOC3, mean HR 1.7, 95% CI 1.1-2.7) were independently associated with incident CVD in T1DM. Conclusions: Elevated serum levels of A2M in T1DM suggest its potential role as a marker—and possibly a mediator—of CVD risk in these patients, alongside APOC3. These findings underscore the significance of specific serum proteins in understanding and managing CVD risk in T1DM.
HostingRepository	PanoramaPublic
AnnounceDate	2025-02-11
AnnouncementXML	Submission_2025-02-11_20:35:00.036.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	supported by repository but incomplete data and/or metadata
PrimarySubmitter	Baohai Shao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	Carbamidomethyl; Label:15N(1); Label:15N(4); Label:15N(3); Label:15N(2)
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-18 07:40:45	ID requested
⏵ 1	2025-02-11 20:35:00	announced

Shao B, Snell-Bergeon JK, de Boer IH, Davidson WS, Bornfeldt KE, Heinecke JW, Elevated levels of serum alpha-2-macroglobulin associate with diabetes status and incident CVD in type 1 diabetes. J Lipid Res, 66(2):100741(2025) [pubmed]

submitter keyword: Alpha-2-macroglobulin, atherosclerosis, case-cohort design, incident cardiovascular disease, Cox proportional regression, MS, parallel reaction monitoring, proteomics.

Baohai Shao
contact affiliation	University of Washington
contact email	bhshao@uw.edu
lab head
Baohai Shao
contact affiliation	University of Washington
contact email	bhshao@uw.edu
dataset submitter

Panorama Public dataset URI