PXD053892

PXD053892 is an original dataset announced via ProteomeXchange.

Title	LRRK2 mediates haloperidol-induced changes in striatal indirect pathway circuits
Description	Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2Rs that are highly expressed in the striatum. Significant side effects of haloperidol, known as extrapyramidal symptoms, lead to motor deficits similar to those seen in Parkinson's disease and present a major challenge in clinical settings. The underlying molecular mechanisms responsible for these side effects remain poorly understood. Parkinson's disease associated LRRK2 kinase has a critical role in striatal physiology and a known link to D2R signaling. Here, we systematically explore convergent signaling of haloperidol and LRRK2.
HostingRepository	PRIDE
AnnounceDate	2025-04-25
AnnouncementXML	Submission_2025-04-25_12:40:39.706.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chuyu Chen
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-07-11 15:02:20	ID requested
⏵ 1	2025-04-25 12:40:40	announced

Chen C, Masotti M, Shepard N, Promes V, Tombesi G, Arango D, Manzoni C, Greggio E, Hilfiker S, Kozorovitskiy Y, Parisiadou L, LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons. Mol Psychiatry, ():(2025) [pubmed]

10.1038/s41380-025-03030-z;

submitter keyword: striatal, haloperidol,LRRK2

Loukia Parisiadou
contact affiliation	Northwestern University - The Feinberg School of Medicine.USA
contact email	loukia.parisiadou@northwestern.edu
lab head
Chuyu Chen
contact affiliation	Northwestern university
contact email	chuyu.chen@northwestern.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/04/PXD053892

PRIDE project URI

• PRIDE
  1. PXD053892
     1. Label: PRIDE project
     2. Name: LRRK2 mediates haloperidol-induced changes in striatal indirect pathway circuits