Based on activities of daily living assessments at admission and followed by a 3-month recovery, ischemic stroke participants were categorized into the groups involving the recovery of little effective (LE) and obvious effective (OE). Differentially expressed proteins (DEPs) derived from proteomic testing of the clinical serum samples (5 LE, 5 OE, and 6 healthy control) and differentially expressed genes (DEGs). In total, 194 DEPs (LE vs healthy control) and 174 DEPs (OE vs healthy control) in serum of the enrolled.