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PXD052245

PXD052245 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA Novel High-Throughput Immunoaffinity LC-MS/MS Assay for P III-NP and other Fragments of Type III Procollagen in Human Serum
DescriptionThe amino-terminal propeptide of type III procollagen (P-III-NP) is used with IGF-I to detect the illicit use of growth hormone and to monitor growth hormone therapy. However, the only currently available assays for P-III-NP are immunoassays, which are not well harmonized. In addition, other fragments of type III procollagen may better evaluate collagen turnover. We developed a high-throughput assay using immunoaffinity enrichment coupled to ultra high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify peptides belonging to three different regions of type III procollagen in human serum simultaneously.
HostingRepositoryPanoramaPublic
AnnounceDate2024-10-28
AnnouncementXMLSubmission_2024-10-28_13:56:05.132.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterHuu Hien Huynh
SpeciesList scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationListGln->pyro-Glu; Oxidation; Carbamidomethyl; Label:13C(6)15N(2); Label:13C(6)15N(4)
InstrumentXevo TQ-S
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-05-13 22:30:40ID requested
12024-10-28 13:56:05announced
Publication List
Huynh HH, Barahona-Carrillo L, Moncrieffe D, Cowan DA, Forrest K, Becker JO, Emrick MA, Thomas A, Thevis M, Eichner D, Byers PH, Miller GD, Hoofnagle AN, A Novel High-Throughput Immunoaffinity LC-MS/MS Assay for P-III-NP and Other Fragments of Type III Procollagen in Human Serum. Drug Test Anal, ():(2024) [pubmed]
Keyword List
submitter keyword: P-III-NP, collagen turnover, single-point calibrator
Contact List
Andy Hoofnagle
contact affiliationUniversity of Washington
contact emailahoof@uw.edu
lab head
Huu Hien Huynh
contact affiliationUniversity of Washington
contact emailhhuynh89@uw.edu
dataset submitter
Full Dataset Link List
Panorama Public dataset URI