Sri Lankan cassava mosaic virus (SLCMV) poses a serious threat to global food security by affecting cassava production in Southeast Asia. The virus causes mosaic patterns in leaves, disrupting photosynthesis and respiration and altering carbohydrate accumulation in tubers. This study aimed to identify proteins associated with cassava mosaic disease (CMD) symptoms in three cassava genotypes: resistant (TMEB419), tolerant (Kasetsart 50), and susceptible (Rayong 11) to CMD.