PXD051424

PXD051424 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Broad proteomics analysis of seeding-induced aggregation of a-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinsons disease pathogenesis
Description	Quantitative total proteomics and phospho-proteomics were used to extensively characterize temporal changes in the total and detergent-insoluble protein fractions isolated from neurons from M83 transgenic mice treated with recombinant a-syn PFF. Protein-protein interaction-based network analysis was utilized to define the biological mechanisms altered due to a-syn aggregation to get a comprehensive understanding of specific mechanisms that can be targeted for rational drug design. Analysis results showed broad changes in several key biological processes such as mechanisms regulating cellular proteostasis including changes in several RNA binding proteins.
HostingRepository	MassIVE
AnnounceDate	2024-05-03
AnnouncementXML	Submission_2024-05-03_10:42:08.640.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Greg Potts
SpeciesList	scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationList	Phospho
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2024-04-13 20:40:54	ID requested
⏵ 1	2024-05-03 10:42:09	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: Parkinsons Disease, M83 mouse model, total and phosphoproteomics

submitter keyword: Parkinsons Disease, M83 mouse model, total and phosphoproteomics

Contact List

Brinda Ravikumar
contact affiliation	AbbVie
contact email	brinda.ravikumar@abbvie.com
lab head
Greg Potts
contact affiliation	AbbVie
contact email	gregory.potts@abbvie.com
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/v07/MSV000094534/