Specific pathogen-free (SPF) 6-8-week-old hamsters were intranasally inoculated with either WH-09 or BA.1, while the control group received intranasal instillation of PBS. After 7 and 14 days post-infection (dpi), the hamsters were euthanized, and lung, heart, and brain tissues were collected for proteomic and phosphoproteomic profiling