BALF and plasma proteomic profiling from the Clinical Response in Pneumonia Therapy (SCRIPT) study which aims to improve treatment strategies for patients with severe pneumonia. The samples were obtained during the early stages of the COVID-19 pandemic (June 15th, 2018 - JulClinical Response in Pneumonia Therapy (SCRIPT) study which aims to improve treatment strategies for patients with severe pneumonia. The samples were obtained during the early stages of the COVID-19 pandemic (June 15th, 2018 - July 6th, 2020) and included patients facing respiratory failure requiring mechanical ventilation in the intensive care unit (ICU).