PXD051059

PXD051059 is an original dataset announced via ProteomeXchange.

Title	Targeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication.
Description	De Antonellis et al. shows the importance of the Ca2+ channel pump ATP2B1 in the regulation of intracellular Ca2+ levels that positively influence SARS-CoV-2 replication in human cells. Our study identifies the mechanism of action of SARS-CoV-2 in the regulation of the expression of ATP2B1 and ATP2A1 loci during infection via FOXO3 transcriptional factor. Furthermore, a small caloxin-derivative molecule (compound PI-7) can inhibit ATP2B1 activity, thus resulting in SARSCoV- 2 impairment. In further support, we have identified a genetic variant within the noncoding upstream region of ATP2B1 in symptomatic patients affected by severe COVID19, thus indicating this polymorphism as a genetic predisposition factor to SARS-CoV-2 infection
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:39:37.128.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vittoria Monaco
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-28 08:16:10	ID requested
1	2024-05-17 04:34:02	announced
⏵ 2	2024-10-22 06:39:37	announced	2024-10-22: Updated project metadata.

10.1038/S44319-024-00164-Z;

submitter keyword: PI3K/Akt ,SARS-CoV-2, ATP2A1, ATP2B1, Ca2+, Forkhead box (Fox) transcription factor, endoplasmic reticulum

Massimo Zollo
contact affiliation	DAI Medicina di Laboratorio e Trasfusionale, ‘Federico II’University of Naples, 80131 Naples, Italy
contact email	massimo.zollo@unina.it
lab head
Vittoria Monaco
contact affiliation	University of Naples "Federico II"
contact email	monacovi@ceinge.unina.it
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD051059
     1. Label: PRIDE project
     2. Name: Targeting ATP2B1 impairs PI3K/Akt/Forkhead box (Fox) transcription factor signaling and reduces SARS-COV-2 infection and replication.