PXD051005

PXD051005 is an original dataset announced via ProteomeXchange.

Title	Biomarkers in Plasma Exosomes Reveal Molecular Pathways of Postoperative Delirium: New Horizons from Diagnosis to Treatment
Description	Background: Delirium diagnosis currently lacks objective biomarkers and is based solely on clinical observation, with incomplete understanding of underlying mechanisms. This study aims to explore the proteomic and metabolomic profiles of exosomes for postoperative delirium (POD) diagnosis and to understand the associated pathophysiological frameworks. Methods: We conducted integrated analyses of proteomics and metabolomics on plasma-derived exosomes from both non-POD controls and POD patients. The study utilized Connectivity Map (CMap) methodology to identify potential small-molecule drugs and performed molecular docking assessments to explore binding affinities with the MMP9 enzyme. Results: Significant differences in exosomal metabolites and proteins between POD patients and controls were identified, emphasizing pathways related to neuroinflammation and blood-brain barrier integrity. Our CMap analysis led to the identification of promising therapeutics, with molecular docking revealing high-affinity MMP9 inhibitors, suggesting new therapeutic avenues for POD. Conclusions: This research highlights MMP9, TLR2, ICAM1, S100B, and glutamate as key biomarkers in POD pathophysiology and underscores the importance of neuroinflammation and blood-brain barrier roles. The findings suggest targeted therapeutic strategies, reinforcing the necessity of multidimensional biomarker analysis in POD intervention, and providing insights into potential new treatment options.
HostingRepository	iProX
AnnounceDate	2024-03-27
AnnouncementXML	Submission_2025-08-26_19:39:13.269.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fuhui Yan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	4800 Plus MALDI TOF/TOF

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-26 22:42:11	ID requested
⏵ 1	2025-08-26 19:39:14	announced

Yan F, Chen B, Ma Z, Chen Q, Jin Z, Wang Y, Qu F, Meng Q, Exploring molecular mechanisms of postoperative delirium through multi-omics strategies in plasma exosomes. Sci Rep, 14(1):29466(2024) [pubmed]

submitter keyword: postoperative delirium (POD), exosome, proteomics, metabolomics, biomarker, neuroinflammation, blood-brain barrier (BBB).

Feng Qu
contact affiliation	Department of Intensive Care Unit, Jining No. 1 People’s Hospital, Jining, China
contact email	rmyyzzeq@163.com
lab head
Fuhui Yan
contact affiliation	Department of Intensive Care Unit, Jining No. 1 People’s Hospital, Jining, China
contact email	richardcarryon@163.com
dataset submitter

iProX dataset URI