To identify and compare protein profiles of supernumerary dental pulp tissue and normal dental pulp tissue. Dental pulp tissues were obtained from supernumerary and permanent teeth. Proteins were extracted and analyzed by Liquid Chromatography-Tandem Mass Spectrometry (LC/MS-MS). MS data were elaborated with MaxQuant for protein identification and quantification. The statistical analysis was conducted using Metaboanalyst software. Differentially expressed proteins (DEPs) were determined (P-value<0.05, FC>2).