PXD050734

PXD050734 is an original dataset announced via ProteomeXchange.

Title	Crosslinking of Ly6a metabolically reprogram CD8 T cells for cancer immunotherapy.
Description	To evaluate the downstream effects of anti-Ly6a crosslinking, we examined the effect of anti-Ly6a antibodies on CD8+ T cell activity in the presence and absence of target tumor cells by high-resolution mass spectrometry proteomic analyses. Spleen cells were isolated from gp10025–33 TCR transgenic mice and incubated for 3 days with IL-2, IFNα, and gp10025–33 peptide. Next, CD8+ T-cells were isolated and incubated overnight with anti-Ly6a antibody (or IgG with or without B16F10 melanoma cells. CD8+ T-cells were then sorted and subjected to proteomic analysis using high-resolution mass spectrometry
HostingRepository	PRIDE
AnnounceDate	2024-08-04
AnnouncementXML	Submission_2024-08-04_04:02:34.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Tamar Geiger
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro 2

Revision	Datetime	Status	ChangeLog Entry
0	2024-03-18 13:47:52	ID requested
⏵ 1	2024-08-04 04:02:35	announced

Dataset with its publication pending

submitter keyword: UVB, CD8 T cells, cancer immunotherapy, T cells metabolism

Prof. Tamar Geiger
contact affiliation	Cancer Proteomics Lab Department of Molecular Cell Biology Weizmann Institute of Science, Rehovot
contact email	tami.geiger@weizmann.ac.il
lab head
Tamar Geiger
contact affiliation	Weizmann Institute of Science
contact email	geiger@tauex.tau.ac.il
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/08/PXD050734

PRIDE project URI

• PRIDE
  1. PXD050734
     1. Label: PRIDE project
     2. Name: Crosslinking of Ly6a metabolically reprogram CD8 T cells for cancer immunotherapy.