2-fold) were filtered based on a >2-fold enrichment in Z629/DMSO and >1 PSM for Z629 in both MIN6 and EndoC-BetaH1. Pathway analysis indicated a role for the Vdac family of proteins which were previously identified to have an important role in Beta-cells during type 2 diabetes (PMCID: PMC6331340). Vdac1 was therefore chosen for validation studies.]]>