PXD050347
PXD050347 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Pediatric papillary thyroid carcinoma |
| Description | Pediatric patients with papillary thyroid carcinoma currently lack widely adopted risk stratification criteria, which leads to a lack of individualized treatment and prognosis assessments. In this retrospective study, 83 pediatric benign (PB), 85 pediatric malignant (PM) and 66 adult malignant (AM) thyroid nodules were evaluated, and 10,426 proteins were quantified by mass spectrometry. We found 243 significantly dysregulated proteins from the PM vs. PB and 122 from PM vs. AM. Function and pathway analyses showed the enhanced activation of the inflammatory and immune system in pediatric malignant patients compared with the others. Nineteen proteins were selected to predict recurrence using a machine learning model with an accuracy of 88.24%. Our study generated a protein-based personalized prognostic prediction model that can stratify pediatric patients with papillary thyroid carcinoma into high or low recurrence risk groups, providing a reference for clinical decision-making and individualized treatment. |
| HostingRepository | iProX |
| AnnounceDate | 2024-03-05 |
| AnnouncementXML | Submission_2024-03-04_19:14:07.597.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yaoting Sun |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2024-03-04 19:12:50 | ID requested | |
| ⏵ 1 | 2024-03-04 19:14:08 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Pediatric papillary thyroid carcinoma, Proteomics, Mass spectrometry, Machine learning, Random survival forest |
Contact List
| Tiannan Guo | |
|---|---|
| contact affiliation | Westlake University |
| contact email | guotiannan@westlake.edu.cn |
| lab head | |
| Yaoting Sun | |
| contact affiliation | Westlake University |
| contact email | sunyaoting@westlake.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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