PXD049792

PXD049792 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of kidneys samples from mice with ADPKD and 3az-treated mice with ADPKD
Description	We performed a proteomic analysis of kidneys samples from mice with ADPKD and 3az- treated mice with ADPKD to explore the mechanisms of 3az treatment in ADPKD. Over 5000 proteins were obtained in kidney tissues from ADPKD group and drug administration group. Among them, 112 and 135 proteins were found up- and down-regulation between two groups, respectively. Gene Ontology (GO) analysis of these dysregulated proteins preliminarily revealed that the proteins regulated by 3az were mainly enriched in many biological processes. In particular, microtubule-based processes, microtubule cytoskeleton formation and mitotic cell cycle changed most significantly and were enriched in a great many of dysregulated proteins following 3az treatment in ADPKD mice. GSEA enrichment analysis demonstrated that compound 3az can down-regulate the proliferation ability of kidney in ADPKD mice. Microtubule-based processes and microtubule cytoskeleton formation have been reported to be associated with retard of cell proliferation and renal cyst expansion.
HostingRepository	PRIDE
AnnounceDate	2024-02-20
AnnouncementXML	Submission_2024-02-20_02:10:21.611.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Qiang Sun
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2024-02-20 01:49:40	ID requested
⏵ 1	2024-02-20 02:10:22	announced

Dataset with its publication pending

submitter keyword: 3az,Mouse, Kidney, ADPKD, Proteomic analysis

Qiang Sun
contact affiliation	Zhejiang University
contact email	sunqiangzai@zju.edu.cn
lab head
Qiang Sun
contact affiliation	Zhejiang University
contact email	sunqiangzai@zju.edu.cn
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2024/02/PXD049792

PRIDE project URI

• PRIDE
  1. PXD049792
     1. Label: PRIDE project
     2. Name: Proteomic analysis of kidneys samples from mice with ADPKD and 3az-treated mice with ADPKD