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PXD049309

PXD049309 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomics Analysis of 5-Fluorouracil- and Gemcitabine-Resistant Cholangiocarcinoma Cell Lines: Identification of Potential Therapeutic Targets and Prognostic Markers
DescriptionCholangiocarcinoma (CCA) poses a significant health challenge, especially in Asian countries. Late-stage diagnoses limit the availability of curative surgical options, underscoring the crucial role of chemotherapy. However, drug resistance presents a formidable obstacle, resulting in recurrent tumors. Despite the revolutionary impact of proteomics on cancer research, the exploration of drug-resistant mechanisms in CCA remains unexplored. In this study, we established 5-fluorouracil (5-FU)- and gemcitabine-resistant CCA cell lines, KKU-213FR and KKU-213GR, derived from the KKU-213A parental line. These cell lines exhibited robust drug resistance, heightened migration, and invasion capabilities.
HostingRepositoryjPOST
AnnounceDate2024-07-03
AnnouncementXMLSubmission_2024-07-03_00:25:38.725.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSittiruk Roytrakul
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListS-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrumentinstrument
Dataset History
RevisionDatetimeStatusChangeLog Entry
02024-02-09 17:00:15ID requested
12024-07-03 00:25:39announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: CCA, 5FU, Gemcitabine
Contact List
Sumalee Obchoei
lab head
Sittiruk Roytrakul
contact affiliationBIOTEC
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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