PXD049033
PXD049033 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Prelamin A interacts with RIPK1 in ZMPSTE24-deficient cells |
Description | To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity labelling combined with mass spectrometry, which allows for temporally and spatially resolved proteomic mapping, to isolate the specific binding proteins of prelamin A. |
HostingRepository | iProX |
AnnounceDate | 2024-01-31 |
AnnouncementXML | Submission_2024-10-12_00:39:36.923.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bing Shan |
SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2024-01-31 01:38:47 | ID requested | |
1 | 2024-01-31 01:39:07 | announced | |
⏵ 2 | 2024-10-12 00:39:46 | announced | 2024-10-12: Update information. |
Publication List
Yang Y, Zhang J, Lv M, Cui N, Shan B, Sun Q, Yan L, Zhang M, Zou C, Yuan J, Xu D, Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1. Nat Cell Biol, 26(4):567-580(2024) [pubmed] |
Keyword List
submitter keyword: Prelamin A, RIPK1 |
Contact List
Daichao Xu | |
---|---|
contact affiliation | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences |
contact email | xudaichao@sioc.ac.cn |
lab head | |
Bing Shan | |
contact affiliation | Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences |
contact email | shanbing@sioc.ac.cn |
dataset submitter |
Full Dataset Link List
iProX dataset URI |