PXD049033

PXD049033 is an original dataset announced via ProteomeXchange.

Title	Prelamin A interacts with RIPK1 in ZMPSTE24-deficient cells
Description	To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity labelling combined with mass spectrometry, which allows for temporally and spatially resolved proteomic mapping, to isolate the specific binding proteins of prelamin A.
HostingRepository	iProX
AnnounceDate	2024-01-31
AnnouncementXML	Submission_2024-10-12_00:39:36.923.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Bing Shan
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2024-01-31 01:38:47	ID requested
1	2024-01-31 01:39:07	announced
⏵ 2	2024-10-12 00:39:46	announced	2024-10-12: Update information.

Yang Y, Zhang J, Lv M, Cui N, Shan B, Sun Q, Yan L, Zhang M, Zou C, Yuan J, Xu D, Defective prelamin A processing promotes unconventional necroptosis driven by nuclear RIPK1. Nat Cell Biol, 26(4):567-580(2024) [pubmed]

submitter keyword: Prelamin A, RIPK1

Daichao Xu
contact affiliation	Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
contact email	xudaichao@sioc.ac.cn
lab head
Bing Shan
contact affiliation	Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
contact email	shanbing@sioc.ac.cn
dataset submitter

iProX dataset URI