Updated project metadata. Ischemic heart disease continues to rank highly among cardiovascular diseases in the world. Myocardial reperfusion (R) is provided with an effective and rapid treatment, however it can lead to fatal results as well as ischemia (I). The goal of this study was to use proteomic analysis to assess the proteins and pathways that changed in H9C2 cardiomyocyte cells exposed to (I) and (R) for durations that represented acute and chronic conditions.