Updated project metadata. Colorectal cancer is a common cancer and causes high mortality worldwide. It is urgent to explore its pathogenesis and seek effective therapeutic strategies. Here, the author showed that EEF1D expression in colorectal cancer cells is required to promote tumor growth and metastasis. Moreover, we further performed the proteomic analysis to gain a deeper mechanistic understanding of EEF1D in CRC. We found that EEF1D interacted with various cancer-related proteins. These interactions further support the importance of EEF1D in colorectal cancer.