PXD047210

PXD047210 is an original dataset announced via ProteomeXchange.

Title	Proteome profiling of BV2 cells with altered ALDH2 enzyme activity
Description	Aldehyde dehydrogenase 2 family member (ALDH2) is a key mitochondrial dehydrogenase that functions in the detoxification of acetaldehyde, and endogenous 4-hydroxy-2-nonenal (4-HNE) and malondialdehyde generated by polyunsaturated fatty acid peroxidation. Whether ALDH2 activity altered microglia cell roles in CNS is unclear. The aim of this study was to reveal proteins expression changes induced by altered ALDH2 activity. After bioinformatic analysis, we detected a total of 3077 confident proteins. differentially expressed proteins were filtered with adj. P value <0.05 and expression fold change <0.83 or >1.20. Reactome pathway analysis revealed dysregulated metabolism of lipids and metabolism.
HostingRepository	iProX
AnnounceDate	2023-11-24
AnnouncementXML	Submission_2024-03-26_00:03:18.248.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Wei Ge
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2023-11-23 19:07:18	ID requested
1	2023-11-23 19:07:29	announced
⏵ 2	2024-03-26 00:03:19	announced	2024-03-26: Update information.

Wang X, Wang J, Chen Y, Qian X, Luo S, Wang X, Ma C, Ge W, pathology. Nat Commun, 15(1):2594(2024) [pubmed]

submitter keyword: proteomics, BV2

Wei Ge
contact affiliation	Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
contact email	gewei@ibms.cams.cn
lab head
Wei Ge
contact affiliation	Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
contact email	gewei@ibms.cams.cn
dataset submitter

iProX dataset URI