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PXD046869

PXD046869 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleOrganelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
DescriptionLysosomes are active sites to integrate cellular metabolism and signal transduction. A collection of proteins enriched at lysosomes mediate these metabolic and signaling functions. Both lysosomal metabolism and lysosomal signaling have been linked with longevity regulation; however, how lysosomes adjust their protein composition to accommodate this regulation remains unclear. Using large-scale proteomic profiling, we systemically profiled lysosome-enriched proteomes in association with different longevity mechanisms. We further discovered the lysosomal recruitment of AMPK and nucleoporin proteins and their requirements for longevity in response to increased lysosomal lipolysis. Through comparative proteomic analyses of lysosomes from different tissues and labeled with different markers, we discovered lysosomal heterogeneity across tissues as well as the specific enrichment of the Ragulator complex on Cystinosin positive lysosomes. Together, this work uncovers lysosomal proteome heterogeneity at different levels and provides resources for understanding the contribution of lysosomal proteome dynamics in modulating signal transduction, organelle crosstalk and organism longevity.
HostingRepositoryMassIVE
AnnounceDate2024-02-01
AnnouncementXMLSubmission_2024-02-01_08:45:23.948.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSung Yun Jung
SpeciesList scientific name: Caenorhabditis elegans (NCBITaxon:6239);
ModificationListOxidation
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-11-11 14:49:23ID requested
12024-02-01 08:45:24announced
Publication List
no publication
Keyword List
submitter keyword: C. elegans lysosome
Contact List
Meng Wang
contact affiliationBaylor College of Medicine
contact emailwmeng@bcm.edu
lab head
Sung Yun Jung
contact affiliationBaylor College of Medicine
contact emailsyjung@bcm.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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