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PXD046517 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleMetabolic, Neurotoxic and Immunotoxic Effects of PFAAs and their Mixtures on the Proteome of Plasma and Head Kidney from Rainbow Trout
DescriptionPFAAs (Perfluoroalkyl acids) are a class of bioaccumulative, persistent and ubiquitous aquatic contaminants. A paucity of toxicological information exists for short chain PFAAs and PFAA mixtures. In order to address these knowledge gaps, we performed a 3-week, aqueous exposure of rainbow trout to 3 different concentrations of a PFAA mixture (50 - 500 ng/L) and individual PFAAs (25 nM of PFOS, PFOA, PFBS or PFBA). Untargeted proteomics and were conducted on the blood plasma and head kidney tissue to evaluate differences in biological effect for congeners and mixtures. The mixture and PFOS exposures significantly altered the abundances of many plasma proteins involved in lipid metabolism and the nervous system. The PFOA and high mixture treatments altered many kidney proteins involved in oxidative stress and inflammation. The findings emphasize the need for more toxicological testing of PFAA mixtures and their potential to cause metabolic dysregulation and neurotoxicity in fish.
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterDenina Simmons
SpeciesList scientific name: Oncorhynchus mykiss; NCBI TaxID: 8022;
ModificationListPhospho; Gln->pyro-Glu; Carbamyl; Carbamidomethyl; Oxidation
Instrument6545 Q-TOF LC/MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-10-30 19:38:16ID requested
12024-04-23 17:07:39announced
Publication List
Pollard S, De Silva AO, Simmons DBD, Metabolic, neurotoxic and immunotoxic effects of PFAAs and their mixtures on the proteome of the head kidney and plasma from rainbow trout (Oncorhynchus mykiss). Sci Total Environ, 928():172389(2024) [pubmed]
Keyword List
submitter keyword: proteomics, blood plasma, head kidney, rainbow trout, PFAAs, Perfluoroalkyl acids
Contact List
Denina Simmons
contact affiliationOntario Tech University
contact emaildenina.simmons@ontariotechu.ca
lab head
Denina Simmons
contact affiliationOntario Tech University
contact emaildenina.simmons@ontariotechu.ca
dataset submitter
Full Dataset Link List
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