Update information. Chronic stress can have lasting effects on some individuals, while there are other individuals who exhibit both susceptibility and resistance to the same stressor [43]. During stressful stimuli, resistant individuals exhibited weaker depression-like behaviors, while susceptible individuals showed increased depression-like behaviors. However, the causal relationship between individual behavioral differences and susceptibility and resistance is unclear. Here, we first distinguish between HPSM and LSPM behaviorally. Since gut research is also a new avenue for exploring behavioral changes, We found that susceptible and resistant mice are g-Desulfovibrio/g-Mycoplasma and its metabolite (tetrahydrocortisone/4,4-dimethyl-5alpha-cholinester-8,14, 24-triene-3 There was also a significant difference in the amount of beta-ol. Because gut bacteria are far from the brain, which has a tight blood-brain barrier. Metabolites, typically produced by gut microbes, first enter the bloodstream and then the brain, ultimately affecting behavior. The prefrontal cortex has long been the focus of stress research. We found that susceptible and resistant mice exhibited different behaviors before and after stress stimulation, and there were differences in the levels of a protein in the hippocampus (Ikbkb) of the brain. Because gut bacteria are far from the brain, and the brain has a tight blood-brain barrier. Metabolites, generally produced by gut microbes, first enter the bloodstream and then the brain, ultimately affecting behavior [46]. So we tried to detect lipid metabolites in plasma as a central axis substance connecting the gut-brain, and interestingly, in plasma, susceptibility and resistance mice also have differential lipids (LPC/SM/PI/TG). Together, these data provide a link between susceptibility and resistance and related behaviors during stressful experiences.