Chronic stress can have lasting effects on some individuals, while there are other individuals who exhibit both susceptibility and resistance to the same stressor [43]. During stressful stimuli, resistant individuals exhibited weaker depression-like behaviors, while susceptible individuals showed increased depression-like behaviors. However, the causal relationship between individual behavioral differences and susceptibility and resistance is unclear. Here, we first distinguish between HPSM and LSPM behaviorally. Since gut research is also a new avenue for exploring behavioral changes, We found that susceptible and resistant mice are g-Desulfovibrio/g-Mycoplasma and its metabolite (tetrahydrocortisone/4,4-dimethyl-5alpha-cholinester-8,14, 24-triene-3 There was also a significant difference in the amount of beta-ol. Because gut bacteria are far from the brain, which has a tight blood-brain barrier.