Update information. Currently, one of the most serious threats in rubber tree is the tapping panel dryness (TPD) that greatly restricts the natural rubber production. Over tapping or ethephon stimulation is regarded as the main cause of TPD occurrence. Although extensive studies have been carried out, the molecular mechanism on the TPD still remains puzzled. In the present study, TMT proteome analysis of barks of rubber trees were performed to extend our understanding of the nature and molecular mechanism underlying TPD.