PXD045944

PXD045944 is an original dataset announced via ProteomeXchange.

Title	WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner
Description	Wiskott–Aldrich syndrome protein-interacting protein family member 1 (WIPF1) is associated with malignant tumor progression. However, molecular links between WIPF1 and gastric cancer (GC) growth and metastasis remain elusive. WIPF1 was detected in GC tissues and cells in cellular and animal models. The molecular regulatory mechanisms of WIPF1 in GC were explored. WIPF1 was overexpressed in GC tissues and cells and high expression of WIPF1 was an independent risk factor for a poor prognosis in patients with GC. In this study, it was demonstrated that WIPF1 increases the proliferation and migration of GC cells in vitro and promotes GC growth and metastasis in vivo by activating PI3K/AKT signaling. Moreover, bioinformatics analysis and subsequent experiments confirmed that myocardin (MYOCD) transactivated WIPF1 expression. Additionally, WIPF1 is necessary for MYOCD to promote the malignant phenotype of GC cells by activating the PI3K/AKT signaling pathway, suggesting that the MYOCD/WIPF1/PI3K/AKT axis may contribute to the onset and development of GC
HostingRepository	iProX
AnnounceDate	2023-10-05
AnnouncementXML	Submission_2024-02-19_19:41:31.331.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Fei Su
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2023-10-06 22:27:52	ID requested
1	2023-10-06 22:28:04	announced
⏵ 2	2024-02-19 19:41:32	announced	2024-02-20: Update Publication

Su F, Xiao R, Chen R, Yang T, Wang D, Xu X, Hou X, Guan Q, Feng M, WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner. iScience, 26(11):108273(2023) [pubmed]

submitter keyword: WIPF1, gastric cancer, myocardin-dependent

Fei Su
contact affiliation	The First Hospital of Lanzhou University
contact email	sufei19881216@whu.edu.cn
lab head
Fei Su
contact affiliation	The First Hospital of Lanzhou University
contact email	sufei19881216@whu.edu.cn
dataset submitter

iProX dataset URI