Update publication information. This study examines the effect of a novel multistrain probiotic mixture on symptoms of allergic rhinitis (AR) and investigate potential targets underlying the probiotic treatment using proteomics. All engaged participants in our study are provided with informed consent, and the study design was approved by an ethics review board. Results imply that the novel probiotic mixture can alleviate rhinoconjunctivitis symptoms in pollen, and the proteome analyses suggested a series of proteins that might be targets underlying the probiotic intervention.