Food protein amyloid fibrils have superior technological,nutritional,sensorial,and physical properties compared to native monomers, butthere is yet insufficient understanding of their digestive fate and safety for wide consumption.By combining SDS,ELISA,fluorenscence,AFM, MALDI-MS, CD microfluidics,and SAXS techniques for the characterization of blg and lysozyme amyloid fibrils subjected to in-vitro gastrointestinal digestion.LC-MS/MS analysis on the fate of blg/lysozyme amyloid fibrils digested in vivo by mice was applied to verify our in vitro results.