HIV-1 infected patients have significantly higher chance to get cancers such as CRC and lung cancer that are not defined in HIV-1/AIDS. However, the systems biological understanding of these HIV-1 associated malignancies (HAM) has not been clearly addressed so far. To this end, we have finished proteomic analysis on the cancer tissues from 4 cases of HACRC. We are performing intensive bioinformatics to address the proteome feature of HACRC, as well as its systems difference from CRC of non-HIV-1 infected people.