More than 20 years ago, the FW2.2 gene was the first cloned gene underlying a Quantitative Trait Locus (QTL) governing fruit size/weight in tomato. However, despite this discovery, the molecular mechanisms by which FW2.2 acts as a negative regulator of cell divisions during fruit growth remain undeciphered. Here we performed a co-immunoprecipitation experiment on protein extract from pericarp of fruits 10 days after anthesis from wild-type and 35S::FW2.2-YFP plants in order to identify interacting proteins of FW2.2.