PXD045111

PXD045111 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteomic analysis of MCL-1 interactors in liver
Description	Mcl1-conditional mice were injected with AAV-LP1-Cre to delete endogenous MCL-1 and with AAV-LP1-Mcl1Flag (FLINT) or AAV-LP1-GFP (wt control). After 14 days, mitochondria were harvest from mouse livers and subjected to anti-FLAG immunoprecipitation. Immune complexes were subjected to LC MS/MS mass spectrometry. Two independent liver mitochondria immunoprecipitations were run in parallel.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_07:39:01.322.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Andy High
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	monohydroxylated residue
Instrument	LTQ Orbitrap Elite

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-09-05 08:17:56	ID requested
⏵ 1	2025-05-06 07:39:02	announced

Publication List

Wright T, Turnis ME, Grace CR, Li X, Brakefield LA, Wang YD, Xu H, Kaminska E, Climer LK, Mukiza TO, Chang CL, Moldoveanu T, Opferman JT, Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. Mol Cell, 84(7):1338-1353.e8(2024) [pubmed]
10.1016/j.molcel.2024.02.035;

Wright T, Turnis ME, Grace CR, Li X, Brakefield LA, Wang YD, Xu H, Kaminska E, Climer LK, Mukiza TO, Chang CL, Moldoveanu T, Opferman JT, Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1. Mol Cell, 84(7):1338-1353.e8(2024) [pubmed]

10.1016/j.molcel.2024.02.035;

Keyword List

submitter keyword: liver, ACSL1, AAV, GFP,MCL1

submitter keyword: liver, ACSL1, AAV, GFP,MCL1

Contact List

Joseph T. Opferman
contact affiliation	Cell & Molecular Biology; St Jude Children's Research Hospital; Memphis, TN
contact email	joseph.opferman@stjude.org
lab head
Andy High
contact affiliation	St Jude Children's Reserach Hospital
contact email	anthony.high@stjude.org
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD045111
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD045111

PRIDE project URI

Repository Record List

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