PXD042078

PXD042078 is an original dataset announced via ProteomeXchange.

Title	A cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
Description	To understand the underlying molecular mechanism of Hdac9-mediated inflammasome activation and motivated by the molecular scaffolding function of HDAC9, we pursued the hypothesis that HDAC9 may serve as a docking site for cytosolic inflammasome components thereby facilitating its rapid formation upon stimulation. We tested this by performing co-immunoprecipitation experiments coupled with mass spectrometry to assess subunits of the inflammasome that interact with HDAC9.
HostingRepository	PRIDE
AnnounceDate	2025-07-10
AnnouncementXML	Submission_2025-07-10_09:00:29.575.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ignasi Forne
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-09 00:01:57	ID requested
⏵ 1	2025-07-10 09:00:30	announced

10.1016/j.immuni.2025.01.003;

Asare Y, Yan G, Schlegl C, Prestel M, van der Vorst EPC, Teunissen AJP, Aronova A, Tosato F, Naser N, Caputo J, Prevot G, Azzun A, Wefers B, Wurst W, Schneider M, Forne I, Bidzhekov K, Naumann R, van der Laan SW, Brandhofer M, Cao J, Roth S, Malik R, Tiedt S, Mulder WJM, Imhof A, Liesz A, Weber C, Bernhagen J, Dichgans M, A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. Immunity, 58(3):555-567.e9(2025) [pubmed]

submitter keyword: inflammation, inflammasome, atherosclerosis,HDAC9, NLRP3

Prof. Dr. Martin Dichgans
contact affiliation	Institute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilian-University (LMU), Munich, Germany
contact email	martin.dichgans@med.uni-muenchen.de
lab head
Ignasi Forne
contact affiliation	Biomedical Center-LMU
contact email	ignasi.forne@lrz.uni-muenchen.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/07/PXD042078

PRIDE project URI

• PRIDE
  1. PXD042078
     1. Label: PRIDE project
     2. Name: A cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation