PXD042071
PXD042071 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | A cross-species proteomic map reveals neoteny of human synapse development - Mouse dataset |
Description | The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins from midgestation to adolescence, we found that PSD maturation in humans separates into three major phases that are dominated by distinct pathways. Cross-species comparisons reveal that the human PSD matures about two to three times slower than other species and contains higher levels of Rho guanine nucleotide exchange factors (RhoGEFs) in the perinatal period. Enhancement of the RhoGEF signaling in human neurons delays the morphological maturation of dendritic spines and functional maturation of synapses, potentially contributing to the neotenic traits of human brain development. In addition, PSD proteins can be divided into four modules that exert stage- and cell type-specific functions, possibly explaining their differential associations with cognitive functions and diseases. Together, our proteomic map of synapse development provides a blueprint for studying the molecular basis and evolutionary changes of synapse maturation. |
HostingRepository | MassIVE |
AnnounceDate | 2023-05-26 |
AnnouncementXML | Submission_2023-05-26_15:35:13.978.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Li Wang |
SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
ModificationList | Oxidation; Acetyl |
Instrument | Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-05-08 19:10:05 | ID requested | |
⏵ 1 | 2023-05-26 15:35:14 | announced |
Publication List
no publication |
Keyword List
submitter keyword: brain, cortex, synapse, PSD, neoteny |
Contact List
Arnold Kriegstein | |
---|---|
contact affiliation | University of California - San Francisco |
contact email | Arnold.Kriegstein@ucsf.edu |
lab head | |
Li Wang | |
contact affiliation | UCSF |
contact email | Li.Wang@ucsf.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000091890/ |