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PXD042068 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleA cross-species proteomic map reveals neoteny of human synapse development - Human V1 dataset
DescriptionThe molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins from midgestation to adolescence, we found that PSD maturation in humans separates into three major phases that are dominated by distinct pathways. Cross-species comparisons reveal that the human PSD matures about two to three times slower than other species and contains higher levels of Rho guanine nucleotide exchange factors (RhoGEFs) in the perinatal period. Enhancement of the RhoGEF signaling in human neurons delays the morphological maturation of dendritic spines and functional maturation of synapses, potentially contributing to the neotenic traits of human brain development. In addition, PSD proteins can be divided into four modules that exert stage- and cell type-specific functions, possibly explaining their differential associations with cognitive functions and diseases. Together, our proteomic map of synapse development provides a blueprint for studying the molecular basis and evolutionary changes of synapse maturation.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterLi Wang
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListOxidation; Acetyl
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-05-08 19:02:33ID requested
12023-05-26 15:36:11announced
Publication List
no publication
Keyword List
submitter keyword: brain, cortex, synapse, PSD, neoteny
Contact List
Arnold Kriegstein
contact affiliationUniversity of California - San Francisco
contact emailArnold.Kriegstein@ucsf.edu
lab head
Li Wang
contact affiliationUCSF
contact emailLi.Wang@ucsf.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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