PXD042067

PXD042067 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	A cross-species proteomic map reveals neoteny of human synapse development - Human main PFC dataset
Description	The molecular mechanisms and evolutionary changes accompanying synapse development are still poorly understood. Here, we generated a cross-species proteomic map of synapse development in the human, macaque, and mouse neocortex. By tracking the changes of >1,000 postsynaptic density (PSD) proteins from midgestation to adolescence, we found that PSD maturation in humans separates into three major phases that are dominated by distinct pathways. Cross-species comparisons reveal that the human PSD matures about two to three times slower than other species and contains higher levels of Rho guanine nucleotide exchange factors (RhoGEFs) in the perinatal period. Enhancement of the RhoGEF signaling in human neurons delays the morphological maturation of dendritic spines and functional maturation of synapses, potentially contributing to the neotenic traits of human brain development. In addition, PSD proteins can be divided into four modules that exert stage- and cell type-specific functions, possibly explaining their differential associations with cognitive functions and diseases. Together, our proteomic map of synapse development provides a blueprint for studying the molecular basis and evolutionary changes of synapse maturation.
HostingRepository	MassIVE
AnnounceDate	2023-05-26
AnnouncementXML	Submission_2023-05-26_15:36:24.496.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Li Wang
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Oxidation; Acetyl
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-05-08 18:49:01	ID requested
⏵ 1	2023-05-26 15:36:24	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: brain, cortex, synapse, PSD, neoteny

submitter keyword: brain, cortex, synapse, PSD, neoteny

Contact List

Arnold Kriegstein
contact affiliation	University of California - San Francisco
contact email	Arnold.Kriegstein@ucsf.edu
lab head
Li Wang
contact affiliation	UCSF
contact email	Li.Wang@ucsf.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000091887/