PXD041647
PXD041647 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of glioma reveals differentially active pathways among high-grade glioma subgroups |
| Description | Glioblastoma (GBM) is a lethal brain tumor without effective treatment options. Data about proteomics in glioma is sparse and it has not yet been integrated into the routine diagnostic work-up or exploited to find potential actionable targets to prevent GBM-induced immune evasion mechanisms and recurrence. We performed proteomic analysis of diffuse glioma samples classified into six subgroups defined by DNA methylation and patient-paired primary and recurrent samples in order to i) provide an inventory of proteins commonly or individually overexpressed in each of the four HGG subgroups compared to the LGG and deduce relevant pathways for each subgroup and ii) identify specific proteins involved in tumor recurrence after surgical removal. The first study revealed largest differences between low-grade (LGG) and high-grade gliomas (HGG), with major changes observed in proteins involved in active calcium-dependent vesicle trafficking (S100 proteins and annexins), effectors of the immunological synapse, proteins involved in Retinoid acid signalling, and proteins involved in extracellular matrix, cytoskeleton, and cell adhesion. Comparative proteomic analysis between LGG and the HGG subgroups also showed consistency with glioma grading. The second study identified FcGamma receptors on activated microglia and complement components as major players inducing short relapsing GBM tumors. In conclusion, specific pathways and proteins represent potential targets to control progression of the distinct subgroups. |
| HostingRepository | MassIVE |
| AnnounceDate | 2025-07-09 |
| AnnouncementXML | Submission_2025-07-09_02:10:26.526.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Katarzyna Buczak |
| SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2023-04-19 06:34:53 | ID requested | |
| ⏵ 1 | 2025-07-09 02:10:26 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Glioblastoma patient-matched primary and recurrent tumors, activated microglia, multiplexed TMT |
Contact List
| Alexander Schmidt | |
|---|---|
| contact affiliation | Biozentrum, Universtiy of Basel, 4056 Basel, Switzerland |
| contact email | alex.schmidt@unibas.ch |
| lab head | |
| Katarzyna Buczak | |
| contact affiliation | Biozentrum, University of Basel |
| contact email | katarzyna.buczak@unibas.ch |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v05/MSV000091739/ |
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