PXD041417

PXD041417 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Biomarkers discovery for progressive supranuclear palsy from the human cerebrospinal fluid using mass spectrometry-based proteomics
Description	Progressive supranuclear palsy (PSP) is a neurodegenerative parkinsonian disorder. This study using CSF samples of PSP patients is a follow-up study to discover biomarkers related to the previous PSP brain results. This study is the first-ever attempt at an in-depth global proteomic study using more than 100 CSF samples for PSP study. In this study, we used the 11-plex isobaric tandem-mass-tag (TMT) technology for more accurate and sensitive quantification of CSF proteins and analyzed them using Orbitrap Fusion Lumos mass spectrometry on 40 PSP and 40 PD patients as well as 40 HC individuals CSF samples for the discovery experiment. These candidate biomarkers discovered in this study will pave the way for the development of reliable PSP biomarkers.
HostingRepository	PRIDE
AnnounceDate	2025-05-06
AnnouncementXML	Submission_2025-05-06_15:34:44.331.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	chanhyun na
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	TMT6plex-126 reporter+balance reagent acylated residue
Instrument	Orbitrap Fusion Lumos

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2023-04-09 06:50:54	ID requested
⏵ 1	2025-05-06 15:34:45	announced

Publication List

Jang Y, Oh S, Hall AJ, Zhang Z, Tropea TF, Chen-Plotkin A, Rosenthal LS, Dawson TM, Na CH, Pantelyat AY, Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid. Clin Proteomics, 21(1):56(2024) [pubmed]
10.1186/s12014-024-09507-3;

Jang Y, Oh S, Hall AJ, Zhang Z, Tropea TF, Chen-Plotkin A, Rosenthal LS, Dawson TM, Na CH, Pantelyat AY, Biomarker discovery in progressive supranuclear palsy from human cerebrospinal fluid. Clin Proteomics, 21(1):56(2024) [pubmed]

10.1186/s12014-024-09507-3;

Keyword List

submitter keyword: cerebrospinal fluid, proteomics,Progressive supranuclear palsy, mass spectrometry, biomarkers

submitter keyword: cerebrospinal fluid, proteomics,Progressive supranuclear palsy, mass spectrometry, biomarkers

Contact List

Chan-Hyun Na
contact affiliation	Institute for Cell Engineering, Department of Neurology, Johns Hopkins University School of Medicine
contact email	chanhyun@jhmi.edu
lab head
chanhyun na
contact affiliation	Johns Hopkins University
contact email	chanhyun.na@gmail.com
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD041417
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/05/PXD041417

PRIDE project URI

Repository Record List

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