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PXD041190 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleIdentification of gravity-responsive proteins in mouse soleus muscle using proteomic analysis
DescriptionThis project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as osteoporosis occurring on the ground by searching serum, bone and skeletal muscle (soleus, extensor digitorum longus) proteomes. The goal of this study is to get better understanding to protect the health of both astronauts and osteoporosis patients. Proteome analyses of skeletal muscles from male C57BL/6J mouse (spaceflight [n=6], hypergravity [n=5], hindlimb unloading [n=5]) were carried out tryptic digestion followed by LC-MS/MS analysis (DDA). The obtained results were searched against UniProt DB by Mascot, and the identified peptides were filtered at 1% FDR threshold by searching against the decoy DB.
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterYayoi Kimura
SpeciesList scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationListunknown modification; L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine; N6-carbamoyl-L-lysine; alpha-aminocarbamoylated residue; Acetyl
InstrumentLTQ Orbitrap Elite
Dataset History
RevisionDatetimeStatusChangeLog Entry
02023-03-29 20:26:51ID requested
12023-09-19 00:41:42announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: mouse, soleus muscle, spaceflight, microgravity, hypergravity, hindlimb unloading
Contact List
Yayoi Kimura
lab head
Yayoi Kimura
contact affiliationYokohama City University
dataset submitter
Full Dataset Link List
jPOST dataset URI
Dataset FTP location
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