PXD040184-1
PXD040184 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons |
Description | Neurodegeneration in the autoimmune disease multiple sclerosis (MS) still poses a major therapeutic challenge. Effective drugs that target the inflammation can only partially reduce accumulation of neurological deficits and conversion to progressive disease forms. Diet and the associated gut microbiome are currently being discussed as crucial environmental risk factors that determine disease onset and subsequent progression. In people with MS (pwMS), supplementation of the short-chain fatty acid (SCFA) propionic acid (PA), as microbial metabolite derived from the fermentation of a high-fiber diet, has previously been shown to regulate inflammation accompanied by neuroprotective properties. We set out to determine, whether the neuroprotective impact of PA is a direct mode of action of SCFAs on central nervous system (CNS) neurons. |
HostingRepository | PRIDE |
AnnounceDate | 2024-06-22 |
AnnouncementXML | Submission_2024-06-22_08:26:02.309.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Gereon Poschmann |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | LTQ Orbitrap Elite |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2023-02-16 10:13:10 | ID requested | |
⏵ 1 | 2024-06-22 08:26:03 | announced |
Publication List
Gisevius B, Duscha A, Poschmann G, St, ü, hler K, Motte J, Fisse AL, Augustyniak S, Rehm A, Renk P, B, ö, se C, Hubert D, Peters K, Jagst M, G, ö, mer A, Todt D, Bader V, Tokic M, Hirschberg S, Krogias C, Trampe N, Coutourier C, Winnesberg C, Steinmann E, Winklhofer K, Gold R, Haghikia A, Propionic acid promotes neurite recovery in damaged multiple sclerosis neurons. Brain Commun, 6(3):fcae182(2024) [pubmed] |
10.1093/braincomms/fcae182; |
Keyword List
submitter keyword: propionic acid, neurons, microbiome, iPSCs,multiple sclerosis, damage, neurodegeneration |
Contact List
Gereon Poschmann | |
---|---|
contact affiliation | Molecular Proteomics Laboratory Heinrich Heine University Düsseldorf Germany |
contact email | gereon.poschmann@hhu.de |
lab head | |
Gereon Poschmann | |
contact affiliation | Molecular Proteomics Laboratory |
contact email | gereon.poschmann@hhu.de |
dataset submitter |
Full Dataset Link List
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PRIDE project URI |
Repository Record List
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