PXD039672

PXD039672 is an original dataset announced via ProteomeXchange.

Title	Molecular chaperone Hsp90 supports adaptive cell size increase in response to chronic stress
Description	Hsf1, well known for its role in acute stress responses, is required for the cell size increase, and that the molecular chaperone Hsp90 is essential for coupling the cell size increase to augmented translation through a translational "rewiring stress response". We propose that this protective process of chronic stress adaptation contributes to the increase in size as cells get older, and that its failure promotes aging.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_06:16:41.900.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Manfredo Quadroni
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2023-01-25 09:12:15	ID requested
1	2023-12-02 08:31:08	announced
⏵ 2	2024-10-22 06:16:42	announced	2024-10-22: Updated project metadata.

10.7554/ELIFE.88658;

submitter keyword: Hsf1,Stress adaptation, cytoplasmic density, Hsp90, chronic stress, proteostasis, aging, senescence, cell size, translation

Didier Picard
contact affiliation	Departement of Molecular and Cell Biology, University of Geneva, Geneva, Switzerland
contact email	didier.picard@unige.ch
lab head
Manfredo Quadroni
contact affiliation	University of Lausanne
contact email	manfredo.quadroni@unil.ch
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/12/PXD039672

PRIDE project URI

• PRIDE
  1. PXD039672
     1. Label: PRIDE project
     2. Name: Molecular chaperone Hsp90 supports adaptive cell size increase in response to chronic stress